On Tuesday, January 18th, 2022, the Centers for Disease Control and Prevention (CDC) elevated its travel recommendation for 22 countries and territories to “Level Four: Very High,” meaning people should avoid traveling to these places at all costs. If they have to, they must make sure they are fully vaccinated before travel. In total, the CDC now lists just over 100 countries and territories at “Level 4.”

For a destination to be considered a Level 4 they must have more than 500 new cases over the past 28 days per 100,000 population.

“Do not travel internationally until you are fully vaccinated,” the CDC says on its website. “Getting vaccinated is still the best way to protect yourself from severe disease, slow the spread of COVID-19, and reduce the number of new variants. The CDC encourages you get a COVID-19 vaccine booster dose if you are eligible.”

The 22 locations included in this update are: Albania, Argentina, Australia, Bahrain, Bermuda, Bolivia, Cape Verde, Egypt, Grenada, Guyana, Israel, Panama, Quatar, Saint Kitts and Nevis, Saint Lucia, São Tomé Príncipe, Sint Maarten, Suriname, Bahamas, British Virgin Islands, Turks and Caicos Islands, and Uruguay.

The CDC also raised another 20 countries to “Level 3: High,” meaning people should be sure they are fully vaccinated before traveling to those areas. Unvaccinated travelers should avoid nonessential travel to those countries. Some of the countries included in this list are Uganda, Kuwait, Jamaica, Costa Rica, and Cuba.

For a destination to be considered a Level 3 they must have 100-500 new cases over the past 28 days per 100,000 population.